Latest update December 2023


Müller, S., Kröger, C., Schultze, J.L., and Aschenbrenner, A.C. (2024). Whole blood stimulation as a tool for studying the human immune system. Eur J Immunol  54, 2350519 [Open Access].

Müller, L., Nasr, A.R., Jux, B., Makdissi, N., Trowbridge, J.W., Schmidt, S.V., Schultze, J.L., Quast, T., Schulte-Schrepping, J., Kolanus, W., and Mass, E. (2024). Differential impact of high-salt levels in vitro and in vivo on macrophage core functions. Molecular Biology Reports  51, 343 [Open Access]

Torres, S.V., Man, K., Elmzzahi, T., Malko, D., Chisanga, D., Liao, Y., Prout, M., Abbott, C.A., Tang, A., Wu, J., Becker, M., Mason, T., Haynes, V., Tsui, C., Shakiba, M.H., Hamada, D., Britt, K., Groom, J.R., McColl, S.R., Shi, W., Watt, M.J., Le Gros, G., Pal, B., Beyer, M., Vasanthakumar, A., and Kallies, A. (2024). Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism. Nature Immunology  25, 496-511 10.1038/s41590-024-01753-9 [Open Access]

Liu, D., Aziz, N. A., Imtiaz, M. A., Pehlivan, G., Breteler, M. M. B. (2024) Associations of measured and genetically predicted leukocyte telomere length with vascular phenotypes: a population-based study. GeroScience, 46 (2), 1947-1970. [Open Access]

Fandrey, C. I., Konopka, P., Jentzsch, M., Zackria, A., Maasewerd, S., Latz, E., Schmid-Burgk, J. L. (2024) Cell Type-Agnostic Optical Perturbation Screening Using Nuclear In-Situ Sequencing (NIS-Seq). bioRxiv 2024.01.18.576210.

Sieckmann, K., Winnerling, N., Silva Ribeiro, D. J., Kardinal, R., Steinheuer, L. M., Schermann, G., Klausen, C., Blank-Stein, N., Schulte-Schrepping, J., Osei-Sarpong, C., Becker, M., Bonaguro, L., Beyer, M., Thurley, K., May-Simera, H., Zurkovic, J., Thiele, C., Ruiz de Almodovar, C., Mass, E., Wachten, D. (2024) BBSome-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue. bioRxiv 2024.01.25.576526.

Silva Ribeiro, D. J., Yuksel, S., Dolf, A., & Wachten, D. (2024). Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue. Methods Mol Biol, 2713, 149-158.

Bassler, K., Schmidleithner, L., Shakiba, M. H., Elmzzahi, T., Kohne, M., Floess, S., Scholz, R., Ohkura, N., Sadlon, T., Klee, K., Neubauer, A., Sakaguchi, S., Barry, S. C., Huehn, J., Bonaguro, L., Ulas, T., & Beyer, M. (2023). Identification of the novel FOXP3-dependent T(reg) cell transcription factor MEOX1 by high-dimensional analysis of human CD4(+) T cells. Front Immunol, 14, 1107397. [Open Access]

Domingos, C., Müller, F. E., Passlick, S., Wachten, D., Ponimaskin, E., Schwarz, M. K., Schoch, S., Zeug, A., & Henneberger, C. (2023). Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity. Cells, 12(2), 331. [Open Access]

Nikolka, F., Karagöz, M. S., Nassef, M. Z., Hiller, K., Steinert, M., & Cordes, T. (2023). The Virulence Factor Macrophage Infectivity Potentiator (Mip) Influences Branched-Chain Amino Acid Metabolism and Pathogenicity of Legionella pneumophila. Metabolites, 13(7), 834. [Open Access]

Wang, B., Wöhler, A., Greven, J., Salzmann, R. J. S., Keller, C. M., Tertel, T., Zhao, Q., Mert, Ü., Horst, K., Lupu, L., Huber-Lang, M., van Griensven, M., Mollnes, T. E., Schaaf, S., Schwab, R., Strassburg, C. P., Schmidt-Wolf, I. G. H., Giebel, B., Hildebrand, F., Lukacs-Kornek, V., Willms, A. G., & Kornek, M. T. (2023). Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma. Front Immunol, 14, 1279496. [Open Access]

Jenster, L.M., Lange, K.E., Normann, S., vom Hemdt, A., Wuerth, J.D., Schiffelers, L.D.J., Tesfamariam, Y.M., Gohr, F.N., Klein, L., Kaltheuner, I.H., Ebner, S., Lapp, D.J., Mayer, J., Moecking, J., Ploegh, H.L., Latz, E., Meissner, F., Geyer, M., Kummerer, B.M., and Schmidt, F.I. (2023). P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. J Exp Med, 220. [Open Access]

Aschenbrenner, A. C., & Bonaguro, L. (2023). huva: A human variation analysis framework to predict gene perturbation from population-scale multi-omics data. STAR Protocols, 4(2), 102193. [Open Access]

Xu, Q., Vogt, A., Frechen, F., Yi, C., Küçükerden, M., Ngum, N., Sitjà-Roqueta, L., Greiner, A., Parri, R., Masana, M., Wenger, N., Wachten, D., & Möglich, A. (2023). Engineering Bacteriophytochrome-coupled Photoactivated Adenylyl Cyclases for Enhanced Optogenetic cAMP Modulation. Journal of Molecular Biology, 168257.

Carraro, C., Bonaguro, L., Srinivasa, R., van Uelft, M., Isakzai, V., Schulte-Schrepping, J., Gambhir, P., Elmzzahi, T., Montgomery, J. V., Hayer, H., Li, Y., Theis, H., Kraut, M., Mahbubani, K. T., Aschenbrenner, A. C., König, I., Fava, E., Fried, H.-U., De Domenico, E., Beyer, M., Saglam, A., & Schultze, J. L. (2023). Chromatin accessibility profiling of targeted cell populations with laser capture microdissection coupled to ATAC-seq. Cell Reports Methods, 3(10), 100598. [Open Access]

Prochnicki, T., Vasconcelos, M. B., Robinson, K. S., Mangan, M. S. J., De Graaf, D., Shkarina, K., Lovotti, M., Standke, L., Kaiser, R., Stahl, R., Duthie, F. G., Rothe, M., Antonova, K., Jenster, L. M., Lau, Z. H., Rosing, S., Mirza, N., Gottschild, C., Wachten, D., Gunther, C., Kufer, T. A., Schmidt, F. I., Zhong, F. L., & Latz, E. (2023). Mitochondrial damage activates the NLRP10 inflammasome. Nat Immunol, 24(4), 595-603. [Open Access]

Wunderling, K., Zurkovic, J., Zink, F., Kuerschner, L., & Thiele, C. (2023). Triglyceride cycling enables modification of stored fatty acids. Nat Metab, 5(4), 699-709. [Open Access]

Yuzeir, A., Bejarano, D. A., Grein, S., Hasenauer, J., Schlitzer, A., & Yu, J. (2023). IntestLine: a shiny-based application to map the rolled intestinal tissue onto a line. Bioinformatics, 39(4). [Open Access]

Nickenig, M., Mangan, M. S. J., Lee, H. E., Symeonidis, K., Henne, A., Kaiser, R., Geißmar, E., Garritsen, H., Abdullah, Z., Hiller, K., Latz, E., & Lauterbach, M. A. (2023). Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1. J Immunol.

Lakrisenko, P., Stapor, P., Grein, S., Paszkowski, L., Pathirana, D., Frohlich, F., Lines, G. T., Weindl, D., & Hasenauer, J. (2023). Efficient computation of adjoint sensitivities at steady-state in ODE models of biochemical reaction networks. PLoS Comput Biol, 19(1), e1010783. [Open Access]

Hackstein, C. P., Spitzer, J., Symeonidis, K., Horvatic, H., Bedke, T., Steglich, B., Klein, S., Assmus, L. M., Odainic, A., Szlapa, J., Kessler, N., Beyer, M., Schmithausen, R., Latz, E., Flavell, R. A., Garbi, N., Kurts, C., Kummerer, B. M., Trebicka, J., Roers, A., Huber, S., Schmidt, S. V., Knolle, P. A., & Abdullah, Z. (2023). Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury. J Hepatol, 79(1), 150-166. [Open Access]

Fox, F. A. U., Liu, D., Breteler, M. M. B., & Aziz, N. A. (2023). Physical activity is associated with slower epigenetic ageing-Findings from the Rhineland study. Aging Cell, 22(6), e13828. [Open Access]

Liu, D., Aziz, N. A., Pehlivan, G., & Breteler, M. M. B. (2023). Cardiovascular correlates of epigenetic aging across the adult lifespan: a population-based study. Geroscience, 45(3), 1605-1618. [Open Access]

Verstegen, N. J. M., Pollastro, S., Unger, P. P. A., Marsman, C., Elias, G., Jorritsma, T., Streutker, M., Bassler, K., Haendler, K., Rispens, T., Schultze, J. L., ten Brinke, A., Beyer, M., & van Ham, S. M. (2023). Single-cell analysis reveals dynamics of human B cell differentiation and identifies novel B and antibody-secreting cell intermediates. Elife, 12. [Open Access]

Mass, E., Nimmerjahn, F., Kierdorf, K., & Schlitzer, A. (2023). Tissue-specific macrophages: how they develop and choreograph tissue biology. Nat Rev Immunol, 23(9), 563-579. [Open Access]

Swietlik, J. J., Barthel, S., Falcomata, C., Fink, D., Sinha, A., Cheng, J., Ebner, S., Landgraf, P., Dieterich, D. C., Daub, H., Saur, D., & Meissner, F. (2023). Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation. Nat Commun, 14(1), 2642. [Open Access]

Alamoudi, E., Schälte, Y., Müller, R., Starruß, J., Bundgaard, N., Graw, F., Brusch, L., & Hasenauer, J. (2023). FitMultiCell: simulating and parameterizing computational models of multi-scale and multi-cellular processes. Bioinformatics, 39(11). [Open Access]

Schälte, Y., Fröhlich, F., Jost, P. J., Vanhoefer, J., Pathirana, D., Stapor, P., Lakrisenko, P., Wang, D., Raimúndez, E., Merkt, S., Schmiester, L., Städter, P., Grein, S., Dudkin, E., Doresic, D., Weindl, D., & Hasenauer, J. (2023). pyPESTO: a modular and scalable tool for parameter estimation for dynamic models. Bioinformatics, 39(11). [Open Access]

Gnirck, A. C., Philipp, M. S., Waterhölter, A., Wunderlich, M., Shaikh, N., Adamiak, V., Henneken, L., Kautz, T., Xiong, T., Klaus, D., Tomczyk, P., Al-Bahra, M. M., Menche, D., Walkenhorst, M., Lantz, O., Willing, A., Friese, M. A., Huber, T. B., Krebs, C. F., Panzer, U., Kurts, C., & Turner, J. E. (2023). Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease. Nat Commun, 14(1), 7372. [Open Access]

Heuser-Loy, C., Baumgart, A. K., Hackstein, C. P., Courrèges, C. J. F., Philipp, M. S., Thaiss, C. A., Holland, T., Evaristo, C., Garbi, N., & Kurts, C. (2023). Conditional NKT Cell Depletion in Mice Reveals a Negative Feedback Loop That Regulates CTL Cross-Priming. J Immunol.

Liu, D., Aziz, N. A., Landstra, E. N., & Breteler, M. M. B. (2023). The lipidomic correlates of epigenetic aging across the adult lifespan: A population-based study. Aging Cell, 22(9), e13934. [Open Access]

Yin, J., Mei, Q., Prinz, M., Abdullah, Z., Panzer, U., Li, J., von Vietinghoff, S., & Kurts, C. (2023). Fate mapping reveals compartment-specific clonal expansion of mononuclear phagocytes during kidney disease. Kidney Int, 104(3), 605-610. [Open Access]

Steiner, S., Fehrer, A., Hoheisel, F., Schoening, S., Aschenbrenner, A., Babel, N., Bellmann-Strobl, J., Finke, C., Fluge, Ø., Froehlich, L., Goebel, A., Grande, B., Haas, J. P., Hohberger, B., Jason, L. A., Komaroff, A. L., Lacerda, E., Liebl, M., Maier, A., Mella, O., Nacul, L., Paul, F., Prusty, B. K., Puta, C., Riemekasten, G., Ries, W., Rowe, P. C., Sawitzki, B., Shoenfeld, Y., Schultze, J. L., Seifert, M., Sepúlveda, N., Sotzny, F., Stein, E., Stingl, M., Ufer, F., Veauthier, C., Westermeier, F., Wirth, K., Wolfarth, B., Zalewski, P., Behrends, U., & Scheibenbogen, C. (2023). Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome - State of the art: Report of the 2nd international meeting at the Charité Fatigue Center. Autoimmun Rev, 22(11), 103452. [Open Acces]

Gopalakrishnan, J., Feistel, K., Friedrich, B. M., Grapin-Botton, A., Jurisch-Yaksi, N., Mass, E., Mick, D. U., Muller, R. U., May-Simera, H., Schermer, B., Schmidts, M., Walentek, P., & Wachten, D. (2023). Emerging principles of primary cilia dynamics in controlling tissue organization and function. EMBO J, e113891. [Open Access]


Hansen, J. N., Kaiser, F., Leyendecker, P., Stüven, B., Krause, J.-H., Derakhshandeh, F., Irfan, J., Sroka, T. J., Preval, K. M., Desai, P. B., Kraut, M., Theis, H., Drews, A.-D., De-Domenico, E., Händler, K., Pazour, G. J., Henderson, D. J. P., Mick, D. U., & Wachten, D. (2022). A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation. EMBO reports, 23(8), e54315. [Open Access]

Henne, A., Vigh, A., Martens, A., Nonnenmacher, Y., Ohm, M., Hosseini, S., More, T. H., Lauterbach, M. A., Garritsen, H., Korte, M., He, W., & Hiller, K. (2022). SiMeEx, a simplified method for metabolite extraction of adherent mammalian cells. Front Mol Biosci, 9, 1084060. [Open Access]

More, T. H., Mozafari, B., Märtens, A., Herr, C., Lepper, P. M., Danziger, G., Volk, T., Hoersch, S., Krawczyk, M., Guenther, K., Hiller, K., & Bals, R. (2022). Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia. Metabolites, 12(11), 1058. [Open Access]

Malik, M. N. H., Waqas, S. F.-u.-H., Zeitvogel, J., Cheng, J., Geffers, R., Gouda, Z. A.-E., Elsaman, A. M., Radwan, A. R., Schefzyk, M., Braubach, P., Auber, B., Olmer, R., Müsken, M., Roesner, L. M., Gerold, G., Schuchardt, S., Merkert, S., Martin, U., Meissner, F., Werfel, T., & Pessler, F. (2022). Congenital deficiency reveals critical role of ISG15 in skin homeostasis. The Journal of Clinical Investigation, 132(3). [Open Access]

Georg, P., Astaburuaga-García, R., Bonaguro, L., ..., Schultze, J. L., Aschenbrenner, A. C., Thibeault, C., Kurth, F., Sander, L. E., Blüthgen, N., & Sawitzki, B. (2022). Complement activation induces excessive T cell cytotoxicity in severe COVID-19. Cell, 185(3), 493-512.e425. [Open Access]

Li, Q., Wang, Y., Sun, Q., Knopf, J., Herrmann, M., Lin, L., Jiang, J., Shao, C., Li, P., He, X., Hua, F., Niu, Z., Ma, C., Zhu, Y., Ippolito, G., Piacentini, M., Estaquier, J., Melino, S., Weiss, F. D., Andreano, E., Latz, E., Schultze, J. L., Rappuoli, R., Mantovani, A., Mak, T. W., Melino, G., & Shi, Y. (2022). Immune response in COVID-19: what is next? Cell Death & Differentiation, 29(6), 1107-1122. [Open Access]

Münzker, J., Haase, N., Till, A., Sucher, R., Haange, S.-B., Nemetschke, L., Gnad, T., Jäger, E., Chen, J., Riede, S. J., Chakaroun, R., Massier, L., Kovacs, P., Ost, M., Rolle-Kampczyk, U., Jehmlich, N., Weiner, J., Heiker, J. T., Klöting, N., Seeger, G., Morawski, M., Keitel, V., Pfeifer, A., von Bergen, M., Heeren, J., Krügel, U., & Fenske, W. K. (2022). Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity. Microbiome, 10(1), 96. [Open Access]

Carraro, C., Bonaguro, L., Schulte-Schrepping, J., Horne, A., Oestreich, M., Warnat-Herresthal, S., Helbing, T., De Franco, M., Haendler, K., Mukherjee, S., Ulas, T., Gandin, V., Goettlich, R., Aschenbrenner, A. C., Schultze, J. L., & Gatto, B. (2022). Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state. Elife, 11, e78012. [Open Access]

Jeong, I., Hansen, J. N., Wachten, D., & Jurisch-Yaksi, N. (2022). Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon. STAR Protocols, 3(3), 101542. [Open Access]

Bonaguro, L., Schulte-Schrepping, J., Ulas, T., Aschenbrenner, A. C., Beyer, M., & Schultze, J. L. (2022). A guide to systems-level immunomics. Nature Immunology, 23(10), 1412-1423. [Open Access]

Bonaguro, L., Schulte-Schrepping, J., Carraro, C., Sun, L. L., Reiz, B., Gemünd, I., Saglam, A., Rahmouni, S., Georges, M., Arts, P., Hoischen, A., Joosten, L. A. B., van de Veerdonk, F. L., Netea, M. G., Händler, K., Mukherjee, S., Ulas, T., Schultze, J. L., & Aschenbrenner, A. C. (2022). Human variation in population-wide gene expression data predicts gene perturbation phenotype. iScience, 25(11), 105328. [Open Access]

Heinz, A., Nonnenmacher, Y., Henne, A., Khalil, M. A., Bejkollari, K., Dostert, C., Hosseini, S., Goldmann, O., He, W., Palorini, R., Verschueren, C., Korte, M., Chiaradonna, F., Medina, E., Brenner, D., & Hiller, K. (2022). Itaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2. Biochim Biophys Acta Mol Basis Dis, 1868(12), 166530. [Open Access]

More, T. H., & Hiller, K. (2022). Complexity of subcellular metabolism: strategies for compartment-specific profiling. Curr Opin Biotechnol, 75, 102711.

Orozco-Ruiz, X., Anesi, A., Mattivi, F., & Breteler, M. M. B. (2022). Branched-Chain and Aromatic Amino Acids Related to Visceral Adipose Tissue Impact Metabolic Health Risk Markers. J Clin Endocrinol Metab, 107(7), e2896-e2905. [Open Access]

Picon-Galindo, E., Latz, E. & Wachten, D. (2022). Primary cilia and their effects on immune cell functions and metabolism: a model. Trends Immunol, 43(5), 366-378.

He, W., Henne, A., Lauterbach, M., Geissmar, E., Nikolka, F., Kho, C., Heinz, A., Dostert, C., Grusdat, M., Cordes, T., Harm, J., Goldmann, O., Ewen, A., Verschueren, C., Blay-Cadanet, J., Geffers, R., Garritsen, H., Kneiling, M., Holm, C. K., Metallo, C. M., Medina, E., Abdullah, Z., Latz, E., Brenner, D., & Hiller, K. (2022). Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages. Nat Metab, 4(5), 524-533. [Open Access]

Mangan, M. S. J., Gorki, F., Krause, K., Heinz, A., Pankow, A., Ebert, T., Jahn, D., Hiller, K., Hornung, V., Maurer, M., Schmidt, F. I., Gerhard, R., & Latz, E. (2022). Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever. PLoS Biol, 20(11), e3001351. [Open Access]

Sieckmann, K., Winnerling, N., Huebecker, M., Leyendecker, P., Juliana Silva Ribeiro, D., Gnad, T., Pfeifer, A., Wachten, D., & Hansen, J. N. (2022). AdipoQ-a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro. Mol Biol Cell, 33(12), br22. [Open Access]

Kessler, N., Viehmann, S. F., Krollmann, C., Mai, K., Kirschner, K. M., Luksch, H., Kotagiri, P., Bohner, A. M. C., Huugen, D., de Oliveira Mann, C. C., Otten, S., Weiss, S. A. I., Zillinger, T., Dobrikova, K., Jenne, D. E., Behrendt, R., Ablasser, A., Bartok, E., Hartmann, G., Hopfner, K. P., Lyons, P. A., Boor, P., Rosen-Wolff, A., Teichmann, L. L., Heeringa, P., Kurts, C., & Garbi, N. (2022). Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing. J Exp Med, 219(10). [Open Access]

Akbal, A., Dernst, A., Lovotti, M., Mangan, M. S. J., McManus, R. M., & Latz, E. (2022). How location and cellular signaling combine to activate the NLRP3 inflammasome. Cell Mol Immunol, 19(11), 1201-1214. [Open Access]


Krämer, B., Knoll, R., Bonaguro, L., ToVinh, M., ..., Aschenbrenner, A. C., Schultze, J. L., & Nattermann, J. (2021). Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. Immunity, 54(11), 2650-2669.e2614. [Open Access]

Blaess, S., & Wachten, D. (2021). The BBSome: a nexus controlling energy metabolism in the brain. J Clin Invest, 131(8). [Open Access]

Wachten, D., & Mick, D. U. (2021). Signal transduction in primary cilia - analyzing and manipulating GPCR and second messenger signaling. Pharmacol Ther, 224, 107836. [Open Access]

Embgenbroich, M., van der Zande, H. J. P., Hussaarts, L., Schulte-Schrepping, J., Pelgrom, L. R., Garcia-Tardon, N., Schlautmann, L., Stoetzel, I., Handler, K., Lambooij, J. M., Zawistowska-Deniziak, A., Hoving, L., de Ruiter, K., Wijngaarden, M. A., Pijl, H., Willems van Dijk, K., Everts, B., van Harmelen, V., Yazdanbakhsh, M., Schultze, J. L., Guigas, B., & Burgdorf, S. (2021). Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation. Proc Natl Acad Sci U S A, 118(31). [Open Access]

Hansen, J. N., Rassmann, S., Stuven, B., Jurisch-Yaksi, N., & Wachten, D. (2021). CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images. Eur Phys J E Soft Matter, 44(2), 18. [Open Access]

van der Zande, H. J. P., Nitsche, D., Schlautmann, L., Guigas, B., & Burgdorf, S. (2021). The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation. Front Immunol, 12, 765034. [Open Access]

Balbach, M., Ghanem, L., Rossetti, T., Kaur, N., Ritagliati, C., Ferreira, J., Krapf, D., Puga Molina, L. C., Santi, C. M., Hansen, J. N., Wachten, D., Fushimi, M., Meinke, P. T., Buck, J., & Levin, L. R. (2021). Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization. Mol Hum Reprod, 27(9). [Open Access]