Consumption of Western-type diets with high lipid and sugar contents contributes to the development of obesity-associated chronic systemic inflammation and various metabolic pathologies. A frequent complication in obesity is the development of increased airway hyperreactivity and airway remodeling, which manifests in obesity-associated asthma. Obese asthmatics develop more frequent and severe exacerbations and respond less to common asthma medications and thus, a better understanding of the mechanism involved in disease mechanisms is necessary. We aim to define the molecular pathways and dissect the contribution of stromal and immune cells and their crosstalks during airway hyperreactivity. These efforts could identify key mechanisms driving the disease and possibly future targeted therapies.